Abstract
Background: The most common benign pathological lesion in women of reproductive age is uterine
leiomyoma. Gestational trophoblastic disease includes tumors and tumor like lesions originating from
trophoblastic tissue. The aim of this study was to find the spectrum of molar pregnancy and uterine
pathologies focusing on gestational trophoblastic disease as no study has been done in the past few years.
Methods: Endometrial and uterine specimens of patients (n=436) between the ages of 15-65 years were
collected from a private hospital in Karachi from December 2018 to December 2019. This cross-sectional
study was carried out by pathological diagnosis of patients’ samples under light microscopy using
hematoxylin and eosin staining. Stratification was done about age and nature of specimen to control the
effect modifiers. The post stratification Chi square test was applied and p value <0.05 was considered
significant.
Results: Mean age of the patients was 36.1 years ±7.8. Total 436 uterine biopsies included 260(59.6%)
hysterectomies, 56(12.8%) endometrial curetting’s, 117(26.8%) evacuation specimens and 3(0.7%)
polypectomies. Common pathologies included 124(28.4%) leiomyomas, 61(14%) proliferative endometrium,
52(11.9%) adenomyosis and 32(7.3%) endometrial polyps. Gestational trophoblastic disease was seen in
9(2.06%). Seven (87.5%) were partial hydatidiform moles, one (12.5%) exaggerated placental site reaction
and one choriocarcinoma. Mole was common between 26-30 years with mean age of 27.2 years and
prevalence was 6/100 abortions.
Conclusion: Leiomyoma was the commonest (28.4%) uterine pathology followed by proliferative
endometrium (14.5%). However, endometrial stromal sarcoma and endometriosis were found 0.2% each.
High prevalence of mole was seen in this study. Partial mole was most common and choriocarcinoma was
least common.
Talat Zehra, Mahin Shams, Salma Parween, Sadaf Razzaq, Yasmin Wahid, Sirajuddaulah Syed. (2020) Spectrum of Pathological Lesions in Uterine Specimens with Focus on Gestational Trophoblastic Disease in Karachi, The Pakistan Journal of Medicine and Dentistry, Volume 9, Issue 4.
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