Abstract
Oral cancer, the most challenging and life threatening disease in the field of dentistry, may start as a
reactive lesion due to constant stimulus from tobacco consumption, transform into a pre-malignant lesion
(dysplastic lesion) and ultimately develop into a cancerous lesion (Invasive carcinoma). There is a
fundamental revolution taking place in the analyzing methods; extraction of biological protein from the
saliva rather than from tissues or blood. Several of the biomarkers have been studied with pro-carcinogenic
effects like Interleukins (ILs), tumor necrosis factor (TNF) and leptin, but only a few have been stated in the
literature, which show anti-cancer characteristics like adiponectin and zinc alpha-2 glycoprotein. This review
explored the diagnostic and prognostic values of a biomarkers zinc alpha-2 glycoprotein (ZAG) in adults
suspected of oral squamous cell carcinoma (OSCC). The PubMed, EMBASE and Google Scholar were
searched for scientific studies reported on the potential mechanism of zinc alpha-2 glycoprotein. All the
research articles were selected in which ZAG is applied solely or in conjunction with other biomarkers in oral
cancer and other cancers. These literatures were carefully assessed to find out and compile the diagnostic
and prognostic values and to inquire therapeutic action of ZAG in the process of carcinogenesis.
Mehwish Feroz Ali, Mervyn Hosein, Saima Butt, Rehan Ahmed Siddiqui. (2020) Zinc α-2 Glycoprotein (ZAG) a Novel Biomarker for the Detection of Oral Squamous Cell Carcinoma, The Pakistan Journal of Medicine and Dentistry, Volume 9, Issue-3.
-
Views
680 -
Downloads
45
Article Details
Volume
Issue
Type
Language
