Abstract
Background: Squamous cell carcinoma (SCC) and adenocarcinoma are the most common esophageal
cancers. Barrett’s esophagus is the change of esophageal stratified squamous epithelium to columnar cells
which if remain undiagnosed follows the dysplasia – carcinoma sequence. The last two decades show a
change in the histologic pattern of esophageal carcinoma. Adenocarcinoma is at majority rate than SCC
in the West, however, in Asia, SCC is still the commonest cancer of esophagus. In this study, we aim to define
a spectrum of premalignant and malignant neoplasms of esophagus in our region.
Methods: This study was done at Dow Diagnostic Research and Reference Laboratory (DDRRL). All the cases
of preneoplastic and neoplastic lesions of esophagus received during the period of 7 years (2009-2015) were
reviewed. The data obtained were subjected to descriptive statistical analysis using SPSS version 21.
Results: Out of 94 premalignant cases, 70 (74.5%) were diagnosed as Barrett’s esophagus, 23 (24.5%) as
dysplasia and 1 (1.1%) as adenoma. From the total of 450 malignant cases, 395 (87.7%) were SCC, 54 (12%)
were adenocarcinoma and a single case of leiomyoma was diagnosed. Grade II SCC was found to be most
the common lesion.
Conclusion: Barrett’s esophagus was more than dysplasia and showed male preponderance. SCC was the
predominant esophageal cancer, which is similar to the other studies in our country. SCC was found more
common in females than males and vice versa for adenocarcinoma. Majority of all the cases belonged to
41-60 years of age group.
Asma Shabbir, Muhammad Asif Qureshi, Nehad Khan, Talat Mirza. (2020) Histopathological Spectrum of Premalignant and Malignant Lesions of Esophagus in the Population of Karachi, The Pakistan Journal of Medicine and Dentistry, Volume 9, Issue-2.
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