Abstract
Obesity, attributable to the interaction of genetic makeup, lifestyle and environment
Factors are a multifactorial disease. However, not all people with similar genetics or same environmental
setup become obese. Currently, extensive research is being conducted regarding increases in the
prevalence of obesity, apparent in many societies, studying their eating habits and physical activity.
Although, people with obesity have the equal distribution of body fat, yet they do not suffer from the same
medical ailments. The recent identification of obesity-risk FTO variants rs9939609 associated with body
mass index (BMI) and risk of obesity in multiple populations has led to the major success in the field of
obesity genetics, making FTO the first locus unequivocally associated with adiposity. The role of FTO
gene as a risk factor of obesity has also been identified by the Genome wide association which is entirely
a new approach. The function of FTO gene was unknown, but recent investigation showed that the FTO
gene regulates ghrelin a key mediator of ingestive behavior, which might explain a predisposition to
increased food intake leading to obesity. People with rs9939609 variant of the FTO gene are at increased
risk of obesity they have higher circulating levels of the hunger hormone ghrelin, and feel hungry soon
after eating a meal. This review focuses on the genetics of FTO gene and the association of each
additionally minor allele of (FTO) rs9939609 single nucleotide polymorphism (SNPs) with the risk of
obesity.
Muhammad Haris Lucky, Saeeda Baig, Zil-e-Rubab. (2015) Understanding the Fat Gene Obesity Common Variant FTO rs9939609, The Pakistan Journal of Medicine and Dentistry, Volume-4, Issue-1.
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