Abstract
Objective: To compared the efficacies between glyceryl trinitrate and Ritodrine as a tocolytic agent in pre-term labour. Study design: Descriptive
cases series. Settings: District Head Quarter Hospital, Faisalabad-Pakistan. Duration: Six months from July 2017 to December 2017. Methodology:
In this study the cases of age 20 to 40 years undergoing pre-term labour were included. The diagnosis of pre-term labour was made on the basis on
clinical examination of regular rhythmic contraction at one/ every 10 minutes and dilation of cervix less than 3 cm. The cases in group A were treated
with transdermal patch of glyceryl trinitrate (10 mg), which is replaced every 24 hours just below the umbilicus and those in group B were treated with
Ritodrine infusion at a dose of 0.05 mg/mint for 24 hours and then tablet Ritodrine of 10 mg every 4 hour. The efficacy was labelled as yes where
rhythmic these contractions stop for 12 hours. Results: In this study there were total 100 cases, 50 in each group. There was no significant difference
in terms of mean age 31.23± 7.11 vs 30.12±6.47 years in group A and B with p= 0.45. There were 16 (32%) cases in group A and 18 (36%) in B with
history of C section with p= 0.88. The efficacy was seen in 44 (88%) of cases in group A as compared to 36 (72%) of cases in group B with p= 0.03.
The mean time taken to stop contractions was 4.33±2.56 vs 7.02±3.39 in group A and B respectively with p= 0.001. Conclusion: Glyceryl trinitrate is
significantly better than Ritodrine in stopping pre-mature labour and this difference is significantly better both in mean time to stop contractions and the
average time taken to delivery
Aisha Khalid, Asad Mahmood Khan, Attia Anwar, Mubin Yousaf, Obaid Anwar, Abida Parveen. (2019) Comparison Between Glyceryl Trinitrate and Ritodrine As a Tocolytic Agent in Pre-Term Labour, Annals of Punjab Medical College, Volume 13, Issue 1.
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