Abstract
Background:Paraphenylene-diamine (PPD)poisoningis an emerging problem of developing African and South Asian countries. This study was done with the objective to determine the clinical lab diagnostic accuracy of serum creatinine phosphokinase in cases initially reportingfacial oedema followed by renal failure and rhabdomyolysis due to paraphenylene-diamine (PPD)poisoning.Methods: It was across-sectional study in which data was retrospectively collected atDistrict Head Quarter (DHQ) Hospitals. Data was collected over a period of one year from Jan-Dec 2018.Data was collected from the patient file records. Data wasanalysed on SPSS version 20. Results: In the present study,658 casesof Kala Pathar poisoning presented and treated. M: Fratio was 5:20. There were 518 (78.8%) females. Majority of the female patients were married 488 (94%). Most common clinical manifestations includedmarked facial oedema; dysphagia and stridor.Post complications includerhabdomyolysis and acute renal failure which developed after two to five days. Initial lab investigations within 6–8 hours after ingestion showed markedincrease in TLC count,ALT and Na+ ions. There was marked elevation of serum CPK (1400±200 U/L) levels after 24 hours.Conclusion:PPD poisoning is more common in females of younger age group belonging to rural areas. Early diagnosis and prompt supportive treatment within 2–12 hours of ingestion can save many lives. There is no specific antidote available for this poison.
Rizwan Zafar Ansari,, Abrar Hussain Khosa, Syed Muhammad Yadain, Shagufta Shafi, Anwar ul Haq†, , Zahid Hussain Khali. (2019) INCIDENCE OF PARAPHENYLENE-DIAMINE POISONING IN THREE DISTRICT HEADQUARTER HOSPITALS OF PAKISTAN, JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD, Volume 31, Issue 4.
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