Abstract
OBJECTIVE: To evaluate anti-hyperglycemic and anti-oxidative effects of Lcarnitine in alloxan induced diabetic albino wistar rats.
METHODS: This quasi-experimental study was conducted at Isra University,
Hyderabad from June 2017 to August 2017. Thirty-six albino wistar male rats
were equally divided into 3 groups (n=12/group); group A (control), group B
(alloxan 150mg/kg intraperitoneally) and group C (alloxan 150mg/kg
intraperitoneally + L-carnitine 500mg/kg orally for 21 days). Diabetes was
induced in group B and C by single intraperitoneal dose of alloxan 150mg/kg
body weight and rats having blood glucose >200mg/dl were labeled as diabetic
rats and included in study. Biochemical (blood glucose, serum insulin and
glutathione peroxidase) and histopathological analysis of pancreas was
performed in all three experimental groups.
RESULTS: Post-experimental body weight in groups A, B and C were noted as
249.58±6.63, 199.08±12.18, 210.58±5.14 grams respectively. The fasting
blood glucose in groups A, B and C were noted as 104.58±7.05, 221.25±8.22,
110.17±12.85 mg/dl respectively (P<0.001). Serum insulin in groups A, B and
C was noted as 1.45±0.083, 0.31±0.16, 1.74±0.23 ηg/ml respectively
(P<0.001). Glutathione peroxidase levels in groups A, B and C were noted as
1.45±0.17, 0.93±0.11, 1.74±0.17 ηg/ml respectively (P<0.001).
Histopathology of pancreas showed reduction in size (mean islet diameter
157±1.5 µm) and number of islets of Langerhans in diabetic rats, while Lcarnitine treated rats have shown compensatory increase in size of islets of
Langerhans (mean islet diameter 210±6.3 µm).
CONCLUSION: L-carnitine therapy is a potent anti-hyperglycemic and antioxidative regimen capable of reducing blood glucose and increasing plasma antioxidant levels
Rizwan Ali Talpur, Kumayl Abbas Meghji, Arsalan Ahmed Uqaili, Navaid Kazi, Ghulam Shah Nizammani, Sumayya Qazi. (2019) ANTI-HYPERGLYCEMIC AND ANTI-OXIDATIVE EFFECTS OF L-CARNITINE ADMINISTRATION IN ALLOXAN INDUCED DIABETIC ALBINO WISTAR RATS, KHYBER MEDICAL UNIVERSITY JOURNAL, Volume 11, Issue 4.
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