Abstract
OBJECTIVE: To examine executive control and self-regulation abilities in survivors of childhood acute lymphocytic leukemia (ALL). METHODS: In this cross-sectional study, thirty-five survivors of childhood ALL from Sahukat Khanum Memorial Cancer Hospital, Children Hospital and Jinnah Hospital, Lahore, Pakistan were selected through convenient sampling technique from March 2013 to February 2014.Thirty-five demographically matched healthy children were recruited from local community as control-group. Trail Making Test (TMT) and Self-regulation Questionnaire was administered to childhood ALL survivors and healthy children by researchers. RESULTS: Mean age of ALL survivors and healthy children was 14.25±2.71 years and 14.34±2.98 years respectively. ALL group showed significant executive control deficit as compared to control group. Mean TMT-part A was 35.25±2.38 seconds and 16.14±2.80 seconds in ALL group and control group respectively (p<0.001) while mean TMT-part B was 105.62±2.38 seconds & 33.42±2.30 seconds in ALL group and control group respectively (p<0.001). In addition, both groups performed significantly different on self-regulation questionnaire. ALL group as compared to control group showed impaired emotional regulation (18.65±1.10 seconds vs. 5.57±0.85 seconds respectively; p<0.001); behavioral regulation (14.97±0.92 seconds vs. 4.68±0.75 second respectively; p<0.001); and cognitive regulation (3.57±0.85 seconds vs. 10.60±1.55 seconds respectively; p<0.001). CONCLUSION: Survivors of childhood ALL have marked deficits in social cognition. Treatment protocols might also focus on psychosocial deterioration for better patient care.KEY WORDS: Executive Function (MeSH); Emotion (MeSH); Trail Making Test (MeSH); Self-Regulation Questionnaire (Non-MeSH); Acute Lymphocytic Leukemia (Non-MeSH); Lymphoproliferative Disorders (MeSH); Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (MeSH); Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (MeSH); Pediatric Cancer (Non-MeSH); Child (MeSH).KMUJ 2018, Vol. 10 No.1EXECUTIVE CONTROL ABILITIES ANDSELF-REGULATION IN SURVIVORS OFCHILDHOOD ACUTE LYMPHOCYTICLEUKEMIA1 1Amara Gul, Sadia Zafar
Amara Gul, Sadia Zafar. (2018) EXECUTIVE CONTROL ABILITIES ANDSELF-REGULATION IN SURVIVORS OFCHILDHOOD ACUTE LYMPHOCYTICLEUKEMIA, KHYBER MEDICAL UNIVERSITY JOURNAL, Volume 10, Issue 1.
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