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Purpose: The purpose of this study is to assess the efficacy of intravitreal injection of Afliberceptin patients with chronic central serous chorioretinopathy (CSCR).
Study Design: Interventional case series.
Place and Duration of Study: Multan Medical and Dental Centre and Bodla Eye Care from February 2019 to February 2020.
Methods: This study was conducted on fifteen eyes with sub-acute to chronic central serous chorioretinopathy. All patients who had undergone previous treatment with laser photocoagulation, intravitreal triamcinolone, or bevacizumab in past 3 months, history of glaucoma (intraocular pressure > 21 mmHg), patients who lost to follow-up, and those with previously vitrectomized eyes were excluded. Patients were treated with a single dose of intravitreal injection of Aflibercept (0.5 mg/0.05 ml). Visual acuity with Log MAR chart and central retinal thickness were studied before and after the injection.
Results: The mean age of the patients was 30.46 years ± 9 years. After one month of intravitreal Aflibercept injection, visual acuity improved from 0.32 Log MAR to 0.173 log MAR and at 3 months (the last follow-up) it was 0.206 Log MAR. Central retinal thickness (CRT) improved from 437 ± 82 µm (at the time of presentation) to 349 ± 67 µm at 1 month post injection. At the last follow-up the mean CRT decreased to 309 ± 121 µm. Except for two eyes, all eyes showed visual improvement. These two eyes had a higher CRT as compared to other participants.
Conclusion: Intravitreal injection of Afliberceptis effective in improving BCVA and decreasing the central retinal thickness in patients central serous chorioretinopathy.
Key Words: Central retinal thickness, Central Serous chorioretinopathy, Aflibercept.
Ali Afzal Bodla, Muhammad Afzal Bodla, Syeda Minahil Kazmi, Ayema Moazzam. (2020) Effects of Intravitreal Aflibercept in Patients with Central Serous Chorioretinopathy, Pakistan Journal of Ophthalmology, Volume 36, Issue 4.
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