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Objective: To determine the effect of retinoic acid on the survivability and growth of chick embryos.
Study design: An experimental study.
Place and duration: Department of Anatomy, Islamabad Regional Centre of College of Physicians and Surgeons, Pakistan from 15th of February, 2009 to 15th of February, 2010.
Methodology: Chicken eggs were divided into an experimental group A and its control group C. Group A was administered 0.3µg of retinoic acid (R2625, Sigma) via yolk sac. The control group was sham injected with saline. The chicks belonging to the experimental embryonic group A1 and its matched control C1 were dissected out at 15th embryonic day and the experimental hatched group A2 and its matched control C2 were dissected out at hatching or day 22 (which ever was earlier). Control and experimental groups were compared for survivability and growth retardation.
Results: At the embryonic stage, in the retinoic acid exposed group A1, 83.3% of chicks were alive while 16.6% were dead. Upon hatching, 80% of the chicks belonging to the experimental group A2 survived, while 20% died. All of the chicks belonging to the control groups were alive. The difference of survivability between the experimental and the control groups was significant at the embryonic stage (p=0.026) as well as at the hatching stage (p=0.011). The mean length and weight of the retinoic acid exposed groups was not significantly different from the control.
Conclusion: This study shows that retinoic acid decreases the survivability of chick embryo. Implicating mechanisms include adverse effects on implantation, inner cell mass population and increased permeability of the fetal membranes.
Ayesha Haque, Muhammad Yunus Khan. (2018) The effect of prenatal administration of Retinoic acid on the survivability and growth of chick embryos. , Isra Medical Journal, Volume 10, 01.
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