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The present study was planned to determine the immunological response of Dera Din Panah (DDP) and Nachi breeds of goats
towards artificial infection with Haemonchus (H.) contortus which is considered among the most widely prevalent
gastrointestinal nematodes (GINs) associated with the lowered production, elevated morbidity and mortality in goats under
various farming systems. To this end, a total of 48 goats of DDP and Nachi breeds (24 of each breed) were administered with
third stage infective larvae of H. contortus through early and late infection protocols. The serum and plasma samples were
tested for immunoglobulins isotypes and histamine concentration through ELISA test, respectively. Adult worm antigens were
used to detect the different antibodies in infected and control goats while histamine concentration was measured through
commercially available histamine-ELISA kit. Results revealed that both breeds reflected a significant (P<0.05) difference in
expression of IgG, IgE antibodies and concentration of histamine. Nachi breed showed a compromised immune response
towards artificial infection with H. contortus as compared to DDP. Overall, lower production of antibodies (IgG, IgE) and
plasma histamine depicted that Nachi goats are comparatively more susceptible to H. contorts infection as compared to DDP
goats. In conclusion, difference in immune response towards H. contortus infection may formulate the basis of selective
breeding of resilient goat breed (DDP) in the area.
Muhammad Imran, Muhammad Sohail Sajid, Rao Zahid Abbas, Muhammad Saqib, Muhammad Nisar Khan, Zia-ud-Din Sindhu, Muhammad Kasib Khan. (2020) IMMUNOLOGICAL RESPONSE OF SELECTED INDIGENOUS GOAT BREEDS OF PAKISTAN TOWARDS ARTIFICIAL INFECTION WITH HAEMONCHUS CONTORTUS, , Volume 57, Issue 3.
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