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Objective: To determine the protective effect of Vitamin C on MSG (Ajinomoto) induced histomorphological
changes in rat ovary.
Study Design:It was randomized control trial.
Place and Duration of Study: This study was carried out in the department of Anatomy, Islamic International
Medical College, Rawalpindi, in collaboration with National Institute of Health (NIH), Islamabad. The study was
conducted from September 2015 to March 2016.
Materials and Methods: Total 45 female rats (Sprague Dawley) were used and divided into 3 groups. The
control group (C) was kept on plain water and normal laboratory diet, while the experimental group A, was
given MSG and experimental group B, was fed on MSG and Vitamin C both, for 4 weeks to induce histological
changes in ovary. All rats were sacrificed after 4 weeks. Ovaries were dissected out and examined for gross and
histological parameters. Results were compared with the control and experimental groups.
Results: In experimental group A, weight of the ovary was increased as compared to the control group. The
histological examination of ovary showed granulosa cell degeneration and decrease in the number of primary
follicles in group A. In addition to MSG, vitamin C was also given to experimental group B by mixing it in drinking
water and the dissected ovary of this group showed changes which were less severe than experimental group A.
Conclusion: Protective effect of vitamin C is proved on MSG induced histomorphological changes in ovary of
rats.
Sumaira Abbasi, Rehana Rana, Kaukab Anjum. (2016) Effect of Vitamin C on Monosodium Glutamate (Ajinomoto) Induced Changes in the Ovary of Rats, , Volume-11, Issue-2.
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