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OBJECTIVE: To find out the correlation between Chronic Idiopathic Urticaria and H.pylori infection and to observe the effect of Eradication therapy.
STUDY DESIGN: Observational study.
MATERIALS AND METHODS: 20 patients giving history of Chronic Idiopathic Urticaria were enrolled in the study. Serological testing for the presence of H. pylori infection done and were
given eradication therapy (Capsule Esomeprazole 40 mg o.d, Tablet Metronidazole 400 mg t.d.s
and Tablet Clarithromycin 500 mg b.i.d) for a period of 2 weeks. Clinical assessment was done
at day 0, 30, 60, 90 and 120 by a scoring system (symptom evaluation scale), H.pylori status was
reassessed at day 60 to confirm eradication effectiveness or to see any relapse of symptoms.
SETTING: The study was conducted by the Department of Pharmacology and Therapeutics,
BMSI, JPMC with the collaboration of Department of Dermatology JPMC Karachi from May 2008
to August 2008.
RESULTS: Among 20 patients, 19 were positive for H.pylori infection and were given eradication therapy. Eradication therapy was successful in 18 patients one patient could not complete
the study and there was relapse in one patient The mean SES scores decreased from 3.73 ±
0.45 on day 0 to 2.52 ± 0.51 on day 30, 1.52 ±0.51 on day 60, 1.15 ± 0.51 on days 90 and 0.47 ±
0.77 on day 120. A percentage change of 59.13% was observed with a p value of <0.002.
CONCLUSION: There is a possible role of H.pylori infection in pathogenesis of chronic idiopathic Urticaria.
Nasreen Qazi, Azam J Samdan, Shahnawaz Jamali, Shamshad Begum, Mahrukh Shah. (2013) Chronic Idiopathic Urticaria and Helicobacter Pylori Infection: Effect of Eradication Therapy on the Relief of Symptoms , Journal of Liaquat University of Medical and Health Sciences, Volume-12, Issue-3.
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