تلخیص
Tamarind is an economically important fruit, widely used in traditional medicine due
to its therapeutic properties. However, its bioactive compounds raise an increased
precaution on its toxicity. This study investigated the potential embryotoxicity and
teratogenicity of Tamarindus indica pulp extracts (2 500 mg/L, 1 250 mg/L, 625 mg/L
and 312.5 mg/L) on the eggs and larvae of zebrafish following a Complete Randomized
Design (CRD) in equal replications. Morphological assessment of fish larvae was
based on total body length (TBL) and trunk tail angle (TTA) at 72h post fertilization
and were subjected to ANOVA (p<0.05) and Linear Regression Analysis. Results on
the growth parameters (TBL and TTA) showed significant difference among the four
treatments in a concentration-dependent manner. At 72hpf, 2,500mg/L suggests the
potential of T. indica pulp extract to induce malformations to exposed larvae. This
study presents the inverse relationship of T. indica pulp extract’s embryotoxicity and
teratogenicity where larvae mortality occurs in high levels of concentration while
malformations form at lower concentrations of T. indica pulp extract.
Irish C. Lobitaña, Rizza Mae E. Virtudazo, Ann Marie P. Delfin, Jhon Niño B. Apura, Jay P. Picardal, Jake Joshua C. Garces. (2020) Embryotoxicity and teratogenicity of tamarind (Tamarindus indica L.) pulp extract using zebrafish (Danio rerio) embryo toxicity assay, Asian Journal of Agriculture and Biology, Volume 8, Issue-4.
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