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Septicemia is a devastating medical condition encountered in many hospitals of developing countries. Hepatorenal dysfunction is traditionally viewed as late feature of septicemia due to its obvious effects on hepatorenal organs. This study was undertaken to establish the possible role of serum biomarkers of liver, kidney and blood in the diagnosis of
septicemia. 101 confirmed patients of septicemia from a tertiary care hospital in Lahore were included. Liver and renal function tests were performed for all patients. Patients were divided into 3 age groups on the basis of age: 30- 50, 51-70 and 71-90 years. In Liver function Tests, ALT (37.62%), AST (50.49%) and ALP (99%) were elevated, Bilirubin was normal in majority of patients while total protein was in normal range in 97.02% patients and the trend of albumin was towards low (44.55%).In Renal function tests, urea was elevated in 71.29% and creatinine in 51.48% patients and in electrolytes Na+ was low in 41.58% patients K+ were normal in majority of patients. Hematological parameters such as WBCs were high in 84.16%, hemoglobin was low in 78.12% and platelets were normal. The most common causes were urinary tract infection (31.68%), bed sores (17.82%), chest infection (12.87%) and wound infection (7.92%). According to this study, diabetes (45.56%) was the main comorbidity of septicemia. Most of the patients were between 51-70 years while septicemia occurred equally in both genders. Major predictors for diagnosis were WBCs, hemoglobin, AST, ALT, ALP, urea and creatinine. Other biomarkers gave no information regarding
septicemia diagnosis. This demands the use of improved diagnostic biomarkers in developing countries.
Riffat Mehboob, Sami Ullah Mumtaz, Zoya Manzoor, Sajid Abaidullah, Fridoon Jawad Ahmad. (2016) Deranged biochemical and hematological profile of septicemia patients in Mayo hospital, Lahore, Punjab University Journal of Zoology, Volume 31, Issue 1.
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