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Arsenic level is rising day by day in various parts of the world including Pakistan as a result of zinc and copper smelting and pesticide usage. Inorganic arsenic (sodium arsenate) other than general lethality additionally can be a teratogenic agent. Present research work is focused on the teratogenic impacts of sodium arsenate given to gravid mice (Mus musculus). Different doses of sodium arsenate 18.25, 37.5 and 75mg/kg B.W. were administered orally at day 6 of gestation (single exposure group) to 15 females/dose group along with one control group
having 15 females, which was given only distilled water. Pups were recovered on 18th day of gestation and fixed for morphometric morphological and histological analysis. Morphometric observations indicated significant (P≤0.05) variations among groups in certain parameters (body weights, crown rump length, head and eye circumferences) against control. Microcephaly, hygroma, skin hemorrhages, scoliosis and appendage deformities among arsenic treated groups were observed. Histological studies revealed abnormalities like spina bifida, cardiac malformations, miss-happened cochlea and oropharynx. It is concluded that sodium arsenate causes teratogenicity in developing mice.
Madeeha Arshad, Asmatullah, Chaman Ara. (2017) Embryotoxic effects of sodium arsenate in Mus musculus, Punjab University Journal of Zoology, Volume 32, Issue 2.
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