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Objective: To evaluate the effectiveness of Dutasteride in patient of Benign Prostatic Hyperplasia (BPH), who are undergoing Transurethral Resection of Prostate in term of mean blood loss.
Study Design: Randomized Control Trial (RCT)
Place and Duration: Department of Urology, Pakistan Institute of Medical Sciences, Islamabad from 5th Feb, 2016 to 5th Aug, 2016
Methodology: Patients age between 50 to 85 years with prostate size more than 40 grams and International prostate symptoms score (IPSS) more than 19 were included and randomly divided into two groups, ie Treatment (Group-I) and Control groups (Group-II). The Treatment group received a 0.5 mg tablet dutasteride daily for two weeks prior to transurethral resection of prostate (TURP) as compared to control group. Post- Transurethral resection of prostate blood loss accessed by measuring hemoglobin level one day preoperatively and on 1st post transurethral resection of prostate.
Results: Among 130 patients studied, the mean age was 60.22+4.04 year and having mean IPSS score of 23.20+4.00. In study, mean change of blood loss in both the groups was 1.85+2.75 and 1.56+1.79 which was statistically significant (p-value 0.468).
Conclusion: The use of Dutasteride preoperatively for two weeks has a significant effect in reducing blood loss during Transurethral Resection of the Prostate (TURP).
Keywords: Benign prostatic Hyperplasia (BPH), International prostate symptoms score (IPSS), Transurethral Resection of the Prostate (TURP), Blood loss, Dutasteride, Per-operative
How to Cite This:
Hina S. Effectiveness of short Pre-operative treatment with Dutasteride on per-operative blood loss in TURP: A Randomized Controlled Trial. Isra Med J. 2021; 13(2): 83-86.
Saddaf Hina, Tariq Mehmood Khan, Hafiz Muhammad Asif Zarif, Ammar Akhtar, Ikram Fareed, Gul Zaman Khan Niazi, Muhammad Abdul Rehman Sikandar . (2021) Effectiveness of short Pre-operative treatment with Dutasteride on per-operative blood loss in TURP: A Randomized Controlled Trial, Isra Medical Journal, Volume 13, Issue 02.
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