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Natural hematopoises has been described by the development of blood cells which in turn is regulated by need of the body. If these regulatory systems were disrupted, the production of these cells becomes excessive. The changes mostly occur in the hematopoietic stem cells (HSC) which normally go on to form blood cells, but defects in the hematopoietic stem cells cause an increase circulation of leukemic cells in the body with threatening effects. The incidences of acute myeloid leukemia (AML) in world are about 0.01% and in Pakistan it is more common in Punjab. Commonly, patients with AML were diagnosed by having genetic alterations. Whereas approximately 30% of AML patients have Fms-like tyrosine kinase 3 (FLT3) gene alterations. AML spread very quickly and if not treated it becomes fatal in the short period of time. Through the understanding of molecular biology of cancer and identification of mutations in AML the advancement in the targeted therapeutics has increased and more better drugs, that target products of protein molecules of mutated genes associated with various cancers, are thus being practiced.
Rubina Sher Muhammad, Zafar Iqbal , Akhtar Tanveer. (2013) A role of FLT3 gene mutation in acute myeloid leukemia patients from Pakistan , Punjab University Journal of Zoology, Volume 28, Issue 1.
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