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Topical collagen on skin wound gift moist state that could stimulate reepithelization, proliferation, and epithelial cell migration to conduct growth factor activity on the wound area. One of the sources of collagen is Sangkuriang catfish [Clarias gariepinus (Burchell, 1822) ‘Sangkuriang’] skin that had low immunoreactivity in the human body. This study aimed to determine the influence of topical treatment with Sangkuriang catfish skin extract on malondialdehyde serum and macrophage total on burn injury. Collagen of Sangkuriang catfish skin was extracted by HCl 2 % for 48 h and neutralized by NaOH 1 M. Sangkuriang catfish skin extract contained amino acid of collagen that could repair and stimulate skin cell. This study was an experimental study that used 24 male Rattus norvegicus strain Wistar were divided into K3, P3, K10, and P10 groups. K group was treated with aquadest topical as a burn healing treatment for 3 d (K3) and 10 d (K10). The P group was treated with topical collagen extract as a burn healing treatment for 3 d (P3) and 10 d (P10). The results showed that treatment by collagen from Sangkuriang catfish skin could not decrease MDA serum on 3rd d and 10 d because of P > 0.05 (P = 0.713). Furthermore, it could not decrease macrophage total on 3rd d (P = 0.427) but significantly decrease to 10 d for K10 and P10. Collagen topical from Sangkuriang catfish could accelerate burn to heal by decreasing macrophages total on 10th d due to P < 0.05 (P = 0.000).
Ary Andini, Retno Handajani, Soetjipto Koesnowidagdo, Miranda Zawazi Ichsan, Luciano Pighinelli. (2020) In vivo Effectivity of Collagen Extract from Clarias gariepinus (Burchell, 1822) ‘Sangkuriang’ on Formation of Malondialdehyde and Macrophages in Burn Healing, , Proc. of the PAS: B; 57, Issue 3.
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