تلخیص
A successful hypoinsulinemia (experimental diabetes type 1) was induced with two consecutive doses of 33mg/kg body weight and 40mg/kg body weight streptOzotocin (STZ), at the gap of four days, in male dwarf goats. Marked hyperglycemia 250m01 (average increase of 278%, P 0.001) and significant glycosuria up to 1.7 to 7 g/dl confirmed the induction of the syndrome. The hypoinsulinemic and control goats were maintained for 14 weeks before slaughtered for obtaining tissues. Marked effects on the morphology of the hypoinsulinemic compare to the control goats have been observed. Increased follicular size with fewer interfollicular stoma and excessively flattened follicular epithelium with the evident indications of inactive state* of the gland are the characteristic of the thyroid in insulin insufficiency. The weight of thyroid did not exhibit a noticeable variation in the comparable groups. however, average follicular epithelial height was measured at 7.26±0.09 vim and 4.22±0.10 jsm in the control and hypoinsulinemic goats respectively. Calcitonin cells remained unaffected in hypoinsulinemia.
ABDUL MAJEED CHEEMA , SADYA JAVAID , RUBINA MUSHTAQ. (2000.) STREPTOZOTOCIN INDUCED HYPOINSULINEMIA ON STRUCTURAL ASPECTS OF THYROID GLAND IN DWARF GOAT, Punjab University Journal of Zoology, Volume 15, Issue .
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