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This study was designed to develop a topical skin-care cream (w/o emulsion) of 4% pomegranate extracts versus its vehicle (the base) as control and evaluate its effects on skin-melanin, skin erythema, skin moisture, skin sebum and TEWL. Concentrated pomegranate (Punica granatum) juice was entrapped in the inner aqueous phase of w/o emulsion. The base containing no extract and a the formulation containing 4% concentrated juice of pomegranate was formulated. The odour was adjusted with few drops of lemon oil. Both the base and the formulation were stored at different storage conditions for a period of four weeks to predict their stability. The stability parameters, i.e., physical stability, centrifugation and pH, were monitored at different time intervals. Both the base and the formulation were applied to the cheeks of 25 healthy human volunteers for a period of 8 weeks. The pharmaceutical stability of creams was achiewed from 4 weeks in-vitro study period. Odour disapperaed with the passage of time due to volatilization of lemon oil. The IRUPXODWLRQH[KLELWHGVLJQL¿FDQW
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and the formulation tended to increase sebum content The results showed a good stability over 4 weeks invitro observation period of both the base and the formulation and the formulation exhibited bleaching, anti LQÀDPPDWRU\DQGPRLVWXUL]LQJHIIHFWV %RWKWKHEDVHDQGWKHIRUPXODWLRQZHUHHOHJDQWDQGDHVWKHWLFZLWK respect to sensory evaluation.
Naveed Akhtar, Rashida Parveen, Barkat Ali Khan, Muhammad Jamshaid, Haroon Khan. (2012) Development of Skin-friendly Dermatological Water-in-Oil Emulsion of Pomegranate Juice, , Volume 49, Issue 4.
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