To compare the mean interappointment pain using Ledermix paste and no intracanal medicament in patients with acute apical periodontitis.Study Design: Randomized controlled trial. stPlace and Duration of Study: Operative Dentistry Department, Watim Dental College, Rawalpindi, from 1stMarch to 31August 2018.Materials and Methods: Sixty patients who were fulfilling the inclusion criteria were selected. Two groups were made Group 1 and Group 2. The patients were divided into these groups based on table of random numbers. Single blind technique was followed while dividing the patients. Group 1 patients had ledermix placed into the tooth and Group 2 patients had no intracanal medicament placed into the tooth. Patient pain score was recorded after 48 hrs using Visual Analogue Scale. SPSS version 23 was used to analyze the data.Results: Mean inter-appointment pain was 3.23±1.43 for Ledermix (Group-1) and for no intracanal medicament (Group 2); the mean inter-appointment pain was 5.87±1.30. A statistically significant difference was recorded with a p-value of 0.005.Conclusion: Patients in which Ledermix was placed as an intracanal medicament experienced significantly less inter-appointment pain as compared to patients having no intracanal medicament (p=0.005) at 48 hours. Hence, ledermix can be effectively used as an intracanal medicament to reduce inter-appointment pain for patients seeking endodontic treatment for acute periapical periodontitis in routine clinical settings