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A rapid, simple and sensitive spectrophotometric method has been developed for the determination of diclofenac sodium in pure and tablet formulations. The method depends on the charge–transfer complexation between diclofenac sodium as n-electron donor with 2,3-Dichloro-5, 6-Dicyano-1,4-Benzoquinone (DDQ) in acetonitrile medium as π-acceptor to give a colored complex which absorbs maximally at 545 nm. Beer’s law has been obeyed in the concentration range of 13-275 µg ml-1 with molar absorptivity of 2.5 × 103 L mole-1 cm-1. The proposed method is precise, accurate and specific for routine quantitative analysis of the drug in bulk and dosage forms.
ASAD RAZA, TARIQ MAHMOOD ANSARI, SHAHIDA BAGUM NIAZI, SYED IFTIKHAR HUSSAIN BUKHARI. (2005) A Simple Spectrophotometric Determination of Diclofenac Sodium in Commercial Dosage Forms using 2,3-Dichloro-5, 6-Dicyano-1,4-Benzoquinone (DDQ), Pakistan Journal of Analytical & Environmental Chemistry, Volume 6, Issue 1.
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