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Purpose: To compare the efficacy of once daily travoprost 0.004% and twicedaily Timolol 0.5% plus dorzolamide 2% combination in primary open angleglaucoma.Material and Methods: This study was conducted at outpatient department,Ophthalmology unit, Khyber Teaching Hospital, Peshawar. Study design wasrandomized controlled trial and (group B receiving Timolol 0.5% andDorzolamide 2% was considered as control group) the duration of the study was6 months in which a total of 136 patients were included. All cases included in thestudy were diagnosed as cases of primary open angle glaucoma. Patients weredivided into two groups i.e. A and B with each group having 68 patients. Patientsin group A were given Travoprost 0.004% eye drops daily and patients in groupB were given eye drops having combination of Timolol 0.5% and Dorzolomide2% twice daily. Patients were advised to come at 6 weeks interval for follow up.At each follow up visit, IOP was recorded.Results: Mean age in Group A was 53 ± 13.26 years while in Group B was 55 ±14.31 years. In Group A 56% patients were male and 44% patients were femalewhere as in Group B 59% patients were male and 41% patients were female.Our results show that Timolol + Dorzolamide was more effective than Travoprostas Timolol + Dorzolamide cause reduction in IOP of at least 20% in 84% patientswhile Travoprost cause reduction in IOP of at least 20% in 80% patients. Also pvaluecalculated at six week is statistically significant).Conclusion: Our study concludes that dorzolamide with timolol is moreefficacious than Travoprost in open angle glaucoma.Key Words: Primary open angle glaucoma, travoprost, Timolol plusdorzolamide.
Farooq Khan, Mubashir Rehman, Omar Ilyas, Mohammad Zeeshan Tahir, Imran Ahmad. (2015) Comparison of Intraocular Pressure Lowering Effect of Travoprost and Timolol / Dorzolamide Combination in Primary Open Angle Glaucoma, Pakistan Journal of Ophthalmology, Volume 31, Issue 4.
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