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Purpose: To determine the effect of topical 0.005% Latanoprost on centralcorneal thickness in patients with Primary Open Angle Glaucoma.Material and Methods: This study was conducted at Eye “A” unit, KhyberTeaching Hospital, Peshawar. Total sample size was 139 eyes. Baseline IOPmeasurement was taken with Goldman applanation tonometer. Central cornealthickness was measured by a single trained doctor using the Quantel®Pachymeter. All patients were prescribed Latanoprost 0.005% eye drops oncedaily in the evening. Follow up was at 2 weeks and 8 weeks.Results: Mean age was 52 years with SD ±2.71. Sixty nine (55%) patients weremale and 56 (45%) were female. Mean difference between baseline CCT andCCT after eight weeks was 4% as mean baseline CCT level was 538 μm withSD ± 1.87 and mean CCT level after 8 weeks was 534 μmwith SD ±2.12.Efficacy of effect of Latanoprost on central corneal thickness of patients withprimary open angle glaucoma was analyzed as Latanoprost was effective inreducing CCT in 104 eyes (75%) of 94 patients and was not effective in 35 eyes(25%) of 31 patients.Conclusion: Our study concludes that topical 0.005% Latanoprost eye dropsreduces the central corneal thickness, so latanoprost therapy requires carefulmonitoring while treating patients with primary open angle glaucoma. Howeverthis reduction in CCT was not ≥ 25 µm from base line reading which is notsignificant enough and hence did not have an effect on IOP reading usingGoldman applanation tonometer.Key words: Latanoprost, central corneal thickness, Primary Open AngleGlaucoma.
Akhunzada Mohammad Aftab, Mubashir Rehman, Sher Akbar Khan, , Farooq Khan, Awais Rauf. (2015) Effect of Topical Latanoprost 0.005% Drops on Central Corneal Thickness in Patients with Primary Open Angle Glaucoma, Pakistan Journal of Ophthalmology, Volume 31, Issue 3.
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