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Purpose: To demonstrate the Intraocular Pressure (IOP) lowering effect oftopical Diltiazem (calcium channel blocker) in comparison to Travoprost (antiglaucomadrug).Material and Methods: The study was conducted on 50 healthy rabbits of localstrain, weighing 1500 to 2000 grams. They were kept at the animal house ofDepartment of Pharmacology, Khyber Medical College Peshawar. Effect ofdrugs was studied on both eyes of conscious rabbits. Rabbits were divided intofour groups i.e. A, B, C and D. Rabbits of group A, B and C were made ocularhypertensive / glaucomatous by injecting weekly sub conjunctivalbetamethasone suspension. The iatrogenic glaucoma of group “A” animals weretreated with topical Diltiazem and group B with topical Travoprost drops. GroupC served as ocular hypertensive control. It received only artificial tears during theresearch period. Group D rabbits were used as normotensive control. They wereneither induced for glaucoma nor did they receive any treatment during theresearch period.Results: Our study revealed that there was 19% (5.00 + 0.25 mm Hg) drop inIntra Ocular Pressure with topical Diltiazem. Its onset of action was quick andduration of action prolonged. Whereas topical Travoprost reduced IOP by 15%(4.00 + 0.25 mm Hg). Topical Diltiazem was found consistent in its intraocularpressure lowering effect as compared to Travoprost.Conclusion: Topical Diltiazem can be used as an alternative anti glaucoma drugin future if found safe in human trials.Key words: Glaucoma, Ocular hypertension, Betamethasone suspension,Calcium Channel Blockers (CCB), Intraocular Pressure (IOP).
Saadat Ullah Khan, Zulfiqar uddin Syed, Zulfiqar Ali. (2015) Topical Diltiazem Vs. Travoprost in Reducing Intraocular Pressure in Ocular Hypertensive / Glaucomatous Rabbits, Pakistan Journal of Ophthalmology, Volume 31, Issue 2.
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