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Purpose: To determine the effect of subconjunctival bevacizumab injection on corneal neovascularization.
Material and Methods: The study included 16 eyes of 8 New Zelland albin rabbits. A 6/0 silk suture was placed intrastromally near the superior limbus in bot eyes of rabbits to induce corneal neovascularization. Eyes were checked weekly fo neovascularization and adjacent conjunctival injection. Subconjunctival injections o 1.25mg and 2.5mg bevacizumab were given in right and left eyes respectively Eyes were examined under the operating microscope. Digital photographs wer taken weekly for 6 weeks and then evaluated by using a computerized imag processing technique and a transparent grid technique to quantify the area o corneal neovascularization and adjacent conjunctival injection.
Results: Corneal neovascularization and adjacent conjunctival injection wer observed by the end of first week. Injections were performed at the second week Only four rabbits could complete the study. Conjunctival injection improve significantly at the first week following injection. Most significant reduction o corneal neovascularization was observed in the second week in both eyes of all rabbits. No recurrence was noted although no repeat injection was given.
Conclusion: Subconjunctival injection of bevacizumab may become an adjunct in the treatment of corneal neovascularization.
Zeynep Ozbek, Rukiye Aydin, Ozlem Barut, Barut Selver, M. Alper Selver, Ali Osman Saatci, Ismet Durak. (2013) Can Subconjunctival Bevacizumab Injection Regress Corneal Neovascularization?, Pakistan Journal of Ophthalmology, Volume 29, Issue 1.
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