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Biotransformation indicates the various chemical modifications, which undergo drugs in the body to give metabolites as new molecules having their own features, generally different from those of drug. Eplerenone (1) is an effective antihypertensive agent, and improve the morbidity and mortality of heart failure. Various transformed products 2-11 up to 2009 were obtained from the biotransformation of eplerenone (1) using human volunteers, dogs and rats. This review may be of general interest, and helpful in the comparative studies among transformed products 2-11, obtained by different ways.
AZIZUDDIN ,. (2017) AN UPDATE ON BIOTRANSFORMATIONAL STUDIES OF EPLERENONE, fuuast Journal of Biology, Volume 7, Issue 1.
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