Abstract
Human immunodeficiency virus (HIV) infection, it is a global health concern mainly lead to
acquired immune deficiency syndrome (AIDS). There are numerous limitations of this infection
particularly in the form of host factors which may limit and interfere HIV-1 replication. The most notable
host factors which hinder HIV-1 DNA propagation is the apolipoprotein B mRNA-editing enzyme,
catalytic polypeptide- like 3G (APOBEC3G). Any genetic polymorphism of this substantial host factor may impact
the host susceptibility pattern to HIV viral infection in different part of the world. The aim of this study to examine
genetic variants (rs6001417, rs35228531, rs8177832) effecting HIV-1 infection.
Method: Three variants of APOBEC3G gene polymorphism were genotyped while using RT-PCR method.
Frequency distribution of these genotypes was evaluated in both the HIV-1 and healthy group.
Results: The rs6001417 CG (p = 0.03) and rs35228531 CT (p = 0.01) genotypes were found as protective
elements, while rs35228531 TT (p = 0.02) and rs8177832 AA (p = 0.03) genotypes had shown susceptibility
against the HIV-1 infection. Our data suggest, rs35228531 CT (p = 0.003) and rs8177832 AA (P = <0.001)
genotypes have predominant incidences in HIV-1 male population than healthy control.
Conclusion: We predict rs6001417 CG, rs35228531 CT as protective and rs35228531 TT, rs8177832 AA
genotypes as a predisposing tool, against the HIV-1 infection in a section of Pakistani population. In addition,
male gender was found predominantly high in both protective genotype rs35228531 CT ( p = 0.003) and
predisposing genotype rs8177832 AA ( p = <0.001). The predominant contribution may help the patient to be
predict about the status of HIV infection, however, extra efforts are required to study larger cohort of patients to
better elucidate the association.
Qaisar Ali, Arshad Jamal, Sajjad Ullah, Ahmed Bilal Waqar. (2019) Male predominant association with Apolipoprotein B mRNAediting enzyme, catalytic polypeptide-like 3G variants (rs6001417, rs35228531, rs8177832) predict protection against HIV-1 infection, Advancements in Life Sciences, Volume 7, Issue 2.
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