Abstract
Objective: To compare and correlate hematological parameters (complete blood picture, prothrombin time, activated partial
thromboplastin time, blood group and factor VIII levels) in obligate female carriers of Hemophilia A with control women.
Study Design: A cross-sectional comparative study
Place and Duration: Department of Pathology, Army Medical College, Rawalpindi from 1st January 2017 1st January 2018.
Methodology: Obligate Female carriers (Group-1) of hemophilia A and control women (Group-2) from all ages were included except
those not meeting inclusion criteria. Nine ml of blood was extracted after informed consent from each healthy control and female
carrier, and was tested for blood complete picture, PT, APTT, Factor VIII and blood groups.
Results: A total of 66 patients were included and 33 were obligate female carriers and 33 females were included as controls. Mean
age of carriers vs controls was statistically insignificant (25+13.1 vs.27+ 11.8, p =0.776). Statistically significant differences were not
observed between mean hemoglobin, mean white cell count, mean platelet count and mean prothrombin time of carriers and
controls. However mean activated partial thromboplastin time was significantly different between two groups (carriers vs controls,
37.09+5.13 vs 31.8+1.92, p=0.000). Factor VIII levels were lower in carriers than in non-carriers. Levels observed were statistically
significant (0.000) and strongly correlated with APTT in carriers vs controls. Blood groups were also statistically significant between
carriers and controls (0.004) and showed significant correlation with factor VIII levels in carriers (0.001).
Conclusion: Factor VIII levels were lower and statistically significant between carriers and controls and also showed statistically
significant correlations with APTT in hemophiliac carrier females. No correlation was found with age, hemoglobin, white cell count,
platelet count, blood grouping and prothrombin time.
Sidra Nosheen Kiani, Maria Basharat. (2020) Correlation of Hematologic parameters with factor VIII levels in obligate female carriers of Hemophilia A, Isra Medical Journal, Volume 12, Issue 2.
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