Abstract
Objective: To determine the role of dual topical antibiotics for prevention of sternal wound infection in patients undergoing coronary
artery bypass grafting surgery.
Study Design: Comparative cross-sectional study.
Place and Duration: Cardiac Surgical department Army Cardiac Centre Lahore from 1st Aug, 2017 to 31st July, 2018.
Methodology: Data was collected on 134 consecutive patients of coronary artery bypass grafting surgery (both Off-Pump & On-Pump)
and were divided into two equal groups. Group A includes patients with use of dual topical antibiotics (Topical Cefoperazonesulbactam and topical Vancomycin) and Group B without the use of topical antibiotic. The primary outcome measure was to assess
sternal wound infection prior to discharge till 30th postoperative day.
Results: Sternal wound infection was found to be more common in Group B than Group A (17.91% vs 5.97%) and was statistically
significant (p 0.005). Deep sternal wound infection(DSWI) did not develop in patients of Group A as compared to 4.47% of patients of
Group B. Deep Sternal wound infection was more common in females than males (p 0.001). DSWI related mortality was none in Group
A verses 1.49% in Group B (0.006).
Conclusion: Topical Cefoperazone-sulbactam plus Vancomycin plays important role in the prevention of sternal wound infection
especially deep sternal wound infection after coronary artery bypass grafting surgery
Vaqar Ilahi Paracha, Tehseen Ahmed, Kaleem Ahmad, Anas Ahmad, Mehboob Sultan. (2019) Experience of dual topical antibiotics for prevention of sternal wound infection in coronary artery bypass grafting surgery, Isra Medical Journal, Volume 11, issue 6.
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