Abstract
Objectives: To determine frequency of thrombocytopenia and its association
with mortality among neonates having probable or culture proven sepsis. Study Design:
Descriptive Analytical study. Setting: Multicentre study done at Neonatology Unit of Teaching
Hospital Dera Ghazi Khan and Nishtar Medical University, Multan. Period: February 2019 to July
2019. Material & Methods: Three hundred neonates with culture proven sepsis were enrolled.
Platelet counts along with frequency of thrombocytopenia (<150000/mm3) and mortality
among all the neonates was recorded. Mortality among different groups according to platelet
counts was compared adopting chi-square test. Results: Out of 300 neonates considered in
the final analysis, 164 (54.7%) were male. Overall, median platelet count was 213.0mm3
. TCP
was present in 78 (26.0%) cases. Among 146 culture proven sepsis cases, 88 (61.8%) had
gram positive while 58 (38.2%) had gram negative pathogens. Cases having thrombocytopenia
had significantly higher mortality (n=26/78, 33.3%) as compared with those who had normal
or increased platelet count (n=25/222, 11.3%) representing a significant p value (<0.00001).
Conclusion: Thrombocytopenia is a common complication of culture proven and probable
neonatal sepsis. Mortality is significantly high in neonatal sepsis along with thrombocytopenia.
Shakeel Ahmad, Nusrat Hussain, Rabia Saleem, Tayyaba Rafique . (2020) Frequency of thrombocytopenia and its association with mortality among neonates having probable or culture proven sepsis., The Professional Medical Journal, Volume 27, Issue 12.
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