Abstract
Objective: The objective of this study was to observe changes in spermatogenesis in the testes of albino rats
exposed to lead acetate.
Study Design:An experimental animals study
Place of Study and Duration: This study was carried out in the Department of Anatomy, Islamic International
Medical College Rawalpindi and at National Institute of Health Islamabad from January toApril, 2009.
Materials and Methods: Male adult rats were exposed to lead acetate with intraperitoneal dose of 4mg/Kg body
weight for 5 days a week for 6 weeks. The animals in groupAwere used as control. The animals of groups B were
treated with lead acetate with specified dose for 6 weeks. After 6 weeks the animals of subgroup B were
sacrificed. The results of these two groups were then compared.
Results: After six weeks, it was observed that the number of spermatogenic cells had decreased in the test
groups as compared with control group (p<0.05).
Conclusion: Lead is toxic for cells of spermatogenic series, injurious to heaith and plays a significant role in
reducing male fertility.
