Abstract
Background: The primary objective of any drug for hyperthyroidism is to control clinical manifestations and maintenance of normal levels of hormonal concentrations. It also targets to prevent the recurrence of disease along with minimizing associated risk factors. In this study, effectiveness of oral anti thyroid agents was checked to normalize altered levels of thyroid hormones due to hyperthyroidism.
Methods: The study was comprised of 40 subjects of whom 30 were experiencing hyperthyroidism and were administered anti-hyperthyroid drugs. 10 patients of hyperthyroidism were not taking any medication. Standard dose regimens of carbimazole and propylthiouracil were employed for all 30 hyperthyroid patients under closed monitoring. Physical as well as biochemical analyses of all subjects were done and thyroid profiling was performed for measuring levels of free thyroxine (fT4), free triiodothyronine (fT3), thyroid stimulating hormone (TSH) and antibodies against thyroglobulin (Tg).
Results: Thyroid profiles of medicated hyperthyroid patients were compared with the profiles of non-medicated group. Statistical analysis appeared with non-significant values for all four parameters.
Conclusion: No significant difference was found between medicated and non-medicated groups. We recommend that combinatorial drugs and new derivatives with better efficacy and fewer side effects should be employed to treat hyperthyroidism.
Maria Fareed Siddiqui, Sidra Hasnain, Zahra Batool, MH Qazi, Muhammad Imtiaz, Ismat Fatima, Rabail Alam. (2014) Clinical effectiveness of Carbimazole and Propylthiouracil for Hyperthyroidism in Patients of Punjab, Pakistan, Advancements in Life Sciences, Volume 2, Issue 1.
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