Abstract
OBJECTIVE: To find out the outcome of Guillain-Barr’e Syndrome after five sessions of Plasmapheresis.
METHODOLOGY: This was prospective, descriptive observational study conducted from January 2018 -
July 2019 in neurology ward 28, JPMC Karachi. Patients above 12 years of age diagnosed as
Guillain-Barr’e Syndrome admitted through OPD and emergency were included. Patients diagnosed on
the basis of clinical findings, cerebrospinal fluid detail report and nerve conduction studies. In
Cerebrospinal fluid detail report, albuminocytologic dissociation was observed. Double lumen catheter
was passed and plasmapheresis was done on every alternate day, 1.5-2.0 liters of plasma was removed
and replaced by 4FFPS, 1000ml of normal saline and 500 ml of haemocoel for patients of diabetic
neuropathy. Outcome of the patients was recorded as complete recovery, residual deficit and mortality.
Patients were followed for six months. Data was analyzed by SPSS version 24.
RESULTS: Eighty nine patients of Guillain-Barr’e Syndrome were enrolled. Male patients were 60
(67.42%) whereas female patients were 29(32.58%).There were 15 patients (16.85%) within 12-20 years of
age, 46 patients (51.68%) in 21-40 years of age, 19 patients (21.34%) from 41-60 years of age, 9 patients
(10.11%) were above 60 years of age, 5 patients (5.62%) died while 64(71.91%) patients were fully
recovered after plasma exchange. Twenty patients (22.47%) were partially recovered with residual motor
weakness.
CONCLUSION: Plasma exchange is a good treatment modality for the Guillain-Barr’e Syndrome patients
Salma Haji. (2019) Outcome of Guillain-Barr’e Syndrome after Five Sessions of Plasmapheresis, Journal of Liaquat University of Medical and Health Sciences, Volume-18, Issue-4.
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