Abstract
OBJECTIVES: Pre-eclampsia is hypertensive and multi-system related disorder of pregnancy. It has
frequently labeled as “disease of theories”. 5- 10% of pregnancies complicated due to pre-eclampsia
and it is most common health problem worldwide. This study intended to estimates the copper, zinc and
magnesium levels in patients with pre-eclampsia.
METHOD: Total eighty subjects were included in the present study, from which 40 voluntaries were
normotensive healthy pregnant women (controls), 40 were pre-eclamptic patients (cases). The subjects
were recruited having symptoms of interest after taking obstetric history, anthropometric and clinical
data. After taking informed consent, blood sample collected and stored for biochemical analysis. The
serum zinc, copper and magnesium levels were analyzed by Atomic Absorption Spectrophotometer. The
study was conducted in biochemistry department during period of eight months from October 2015 to
June 2016.
RESULTS: Total eighty subjects were included in present study. The trace elements decreased and
shows significant difference between control healthy pregnant and pre-eclamptic women (p<0.05). The
mean difference of copper (0.15±0.07), zinc (2.94±0.45) and Mg++ (0.15±0.09) mg/dl for the cases group
and for control group copper was (0.20±0.03), zinc (5.11±0.21) and Mg++ (2.17±0.21) mg/dl respectively.
CONCLUSION: Trace elements are essential for the healthy pregnancy, suppressed concentration of
serum Zinc, Copper and Magnesium may put forward the possible involvement in the pathology of
pre-eclampsia. The aim of this study was to protects the mothers as well as her coming newborn from
such life threating disease.
Bushra Jamal, Farheen Shaikh, Muhammad Yousuf Memon. (2017) To Determine the Effects of Copper, Zinc and Magnesium in Patients with Pre-Eclampsia, Journal of Liaquat University of Medical and Health Sciences, Volume-16, Issue-1.
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