Abstract
OBJECTIVE: To evaluate the biochemical significance of Hyaluronic acid in liver fibrosis among
chronic hepatitis C patients to eliminate repetitive liver biopsies.
METHODOLOGY: Cross Sectional Comparative Analytical Study at FPGMI, Shaikh Zayed
Hospital, Lahore from January 2017 to December 2017. This cross-sectional study, included patients of
chronic hepatitis C (n = 250) along with controls (n =100). Serum hyaluronic acid assay (patients &
controls) was performed using enzyme linked binding protein assay, using a capture molecule known
as hyaluronic acid binding protein (HABP) along with quantitative Echelon (Echelon biosciences Inc.
USA) used as reference standard.
RESULTS: Total 350 participant both male and females participated for this study from these 350
samples, 100 normal samples were recruited as control group and 250 diagnosed cases of chronic
hepatitis C patients were recruited as case study group. Serum Hyaluronic acid was significantly
(P<0.001) elevated in patients (195.77 ±6.67) compared to controls (110.2 ±0.79) irrespective of gender
involvement.
CONCLUSION: The current findings showed significant involvement of HA in early prognosis of liver
fibrosis and cirrhosis among chronic HCV patients that would probably useful to reduce repetitive liver
biopsy.
Muhammad Akram, Ali Raza Memon, Farman Ullah Farman, Muhammad Imtiaz Shafiq. (2018) Hyaluronic Acid act as a Non - Invasive Marker for Diagnosis of Liver Fibrosis in the Patients of Chronic Hepatitis C, Journal of Liaquat University of Medical and Health Sciences, Volume-17, Issue-3.
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