Abstract
OBJECTIVE: The pre-eclampsia is most common hypertensive and life threatening disorder during
pregnancy. Abnormal placenta may be involved in the pathogenesis of pre-eclampsia. Co-Enzyme Q10
and trace elements has been proposed as novel factors concerned in development of pre-eclampsia.
STUDY DESIGN: Cross sectional, comparative study
SETTING: Study was conducted in Biochemistry department Liaquat University of Medical & Health
Sciences Jamshoro and patients were recruited from department of Obstetrics & Gynecology Liaquat
University Hospital Jamshoro / Hyderabad
DURATION: 1st February 2015 to 30th October 2015.
METHODS: Total 210 volunteers were recruited, from which 50 volunteers were normotensive healthy
pregnant women as a control and 160 were pre-eclamptic patients as cases. The subjects were recruited
based on sign and symptoms, taking obstetric history, anthropometric, clinical data and collecting
blood sample from volunteers. The CoQ10 was evaluated on HPLC while zinc, copper and magnesium
on Atomic Absorption Spectrophotometer.
RESULTS: The plasma Co-Enzyme Q10 levelwere found decreased in pre-eclamptic patients (mean
±S.D) (0.22±0.09)μg/dl as compared with control group(1.08±0.37) μg/dl with significant difference of
p<0.05. Serum zinc, copper and magnesiumlevels in pre-eclampsia were decreased significanlty, it was
noted as (2.94±0.44), Cu++ (0.19±0.09) and Mg++(1.16 ± 0.08)mg/dl as compared with normotensive women
(5.09±0.29), (0.36± 0.03) and (2.15± 0.09) mg/dl with significant difference of p<0.05 respectively.
CONCLUSION: The observation showed that the CoQ10 and trace elements are essential for the healthy
pregnancy, declined concentration of CoQ10 and essential trace elements may put forward the possible
involvement in the pathology of pre-eclampsia.
Farheen Shaikh, Tazeen Shah, Shafaq Ansari, Sanum Dahri. (2017) To Determine the Role of Co-Enzyme Q10 and Trace Elements in Patient with Pre-Eclampsia - A Cross Sectional Study in Hyderabad, Journal of Liaquat University of Medical and Health Sciences, Volume-16, Issue-2.
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