Abstract
BACKGROUND: Diabetes Mellitus is a global problem caused by the deficiency of Insulin secretion
either absolute or relative. Treatment options are Insulin and oral glucose lowering drugs. Current study
was designed to find out the glucose lowering properties of S-allylcysteine a garlic derivative sulfur
containing amino acid.
OBJECTIVE: To compare blood glucose lowering effects of S-allylcysteine with gliclazide in diabetic rat
model.
STUDY DESIGN, PLACE AND DURATION: This 3 months animal study was carried out in animal house
of ISRA University Hyderabad from August 2014 to Oct 2014.
MATERIAL AND METHODS: 32 Male Wistar Rats were randomly divided into 4 equal groups A, B, C and
D after selection through non-probability purposive sampling. Group A and B served as positive and
negative controls respectively. Diabetes was induced in Group B, C and D by injecting alloxan at the
dose of 120 mg/kg according to the weight of rats. Rats in group C and D were treated with
S-allylcysteine (150 mg/kg), gliclazide (5 mg/kg) respectively. Random blood sugar levels of all groups
were measured after weeks 1, 2 & 3. The data was analyzed by SPSS version 21.0.
RESULTS: Blood glucose levels after 2nd and 3rd week were 264.3 ± 43.16 vs. 218.75 ± 36.38 (p=0.0001)
for SAC and 229.0 ± 89.87 vs. 241.0 ± 48.19 mg/dl for Gliclazide (p=0.001) while at the end of 3rd week
results for two control groups were non-significant statistically (p-0.07 and0.09).
CONCLUSION: It is concluded that S-allylcysteine possess blood glucose lowering properties that are
comparable to gliclazide.
Mashkoor Ahmed Ansari, Qamar Zaman Phull, Ashique Ali Arain, Abdul Rahim Memon, Sadia Kazi, Palwasha Abbasi. (2017) Comparison between S-Allyl Cysteine and Gliclazide in Lowering the Blood Glucose Levels in Diabetic Rats, Journal of Liaquat University of Medical and Health Sciences, Volume-16, Issue-2.
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