Abstract
OBJECTIVE: To find out association of serum C - reactive protein (CRP) with obesity as an
inflammatory marker in obese pregnant women as compared to non-obese pregnant women.
METHODS: This comparative observational study was carried out in the Department of Biochemistry,
Peoples Medical College for Girls Nawabshah, during the period of January 2010 to December
2010. A total of eighty pregnant women of age range 20 – 40 years in their 3rd trimester were recruited in the study. Of these forty were obese and forty non-obese women. Non-obese pregnant
women were grouped as control group. Serum C-reactive protein was measured by ELISA
method. Data analysis including independent t-test and correlation analysis was carried out. P
value up to 0.05 was considered significant.
RESULTS: Serum C - reactive protein concentrations were significantly higher (P<0.001) in obese
pregnant women as compared to control group (9.1 ± 0.12 mg /L vs 4.3 ± 0.16 mg /L), which indicate ongoing low grade systemic inflammation at more advanced level in obese pregnant
women.
CONCLUSION: In pregnant women, higher BMI is associated with higher C-reactive protein concentration. These findings highlight a state of low grade systemic inflammation in obese pregnant women. Measures should be taken to control profound weight increase during pregnancy to
avoid complications during or after pregnancy.
Habibullah Shaikh, Yasmin Shaikh, Ghulam Sarwar Shaikh , Rasool Bux Shaikh . (2012) Elevated Serum C - Reactive Protein Level in Obese Pregnant Women , Journal of Liaquat University of Medical and Health Sciences, Volume-11, Issue-1.
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