Abstract
Background: Amlodipine is a Ca++ channel blocker, routinely used for treatment of hypertension. The mechanism underlying its anti-hypertensive effect is dilatation of blood vessels. Testosterone, the hormone
produced by testis, is responsible for development of male sexual secondary characteristics. The aim of
study was to find out the effect of Ca++ channel blocker, Amlodipine besylate on serum testosterone level in
male albino rats.
Methods: Duration of study was 30 days and conducted in department of pharmacology, 24 male Albino
rats were grouped into 4 groups (each having 6). Group A was control group, Group B, C and D were treated with Amlodipine Besylate drug at doses 0.07, 0.14 and 0.28mg/kg body weight respectively (Suspension
of 5 mg tablet of Amlodipine dissolved in 10 ml distilled water prepared and further diluted to 1:10ml with
distilled water). Independent t test and ANOVA with Tukey’s test were used for comparison of quantitative
variables with in groups.
Results: Serum testosterone level reduced in groups treated with Amlodipine. Serum testosterone level of
control group is 11.22 while group B, C and D were 4.7, 2.6 and 0.7 respectively. Serum FSH level of control
group is 0.10±0.01 while group B, C and D were 0.24±0.35, 0.34±0.40 and 0.08±0.03 respectively. It showed
that increasing the dose of Amlodipine markedly reduce testosterone level and increases FSH level in male
albino rats.
Conclusion: Amlodipine severely reduce level of serum testosterone (p=0.001) and increases FSH level
(p=0.305) which can lead to infertility in male albino Rats.
Rahimullah Rahi, Shahid Ali, Abdullah Jan, Syed Azhar Hussain Zaidi, Zubaida Anwar, Sumaira Deen Muhammad. (2020) Evaluate the Effect of Amlodipine Besylate on Testosterone and Fertility of Male Albino Rats, The Pakistan Journal of Medicine and Dentistry, Volume 9, Issue-3.
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