Abstract
Renal disease and dysfunction is a worldwide public health problem. The underlying pathology in most renal
disease is glomerulopathy, largely referred to as glomerulonephritis. It can be primary or secondary to other
diseases. A range of morphological patterns was observed in this condition, each with different
etiopathogenetic mechanisms, diverse clinical presentation, disease progression and therapeutic
responses. We searched the literature using Hinari, PubMed and Google Scholar, for appropriate studies. This
review was conducted by employing specified methods and structures using histopathology-confirmed
data during the year 2011 to 2020. Thirty-five studies consisting of 13,423 reported renal biopsy cases were
covered in this review. The most common indication of the renal biopsy was nephrotic syndrome followed
by proteinuria and nephritic syndrome. Focal segmental glomerulosclerosis, minimal change disease, and
mesangio-capillary glomerulonephritis among others, were the most frequently reported primary patterns of
glomerulopathies. Glomerular diseases remain poorly characterized due to the scarcity of data on
histo-morphological patterns of glomerulopathies. The development of registries regarding renal biopsy may
offer a chance to characterize the pervasiveness and patterns of glomerulopathies and have a positive
impression on chronic/end stage renal disease analysis and treatment since most glomerular diseases are
complaisant to treatment.
Anam Shaikh, Fouzia Lateef, Talat Mirza. (2021) Histomorphological Spectrum of Glomerulopathies: A Review, The Pakistan Journal of Medicine and Dentistry, Volume 10, Issue-1.
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