Abstract
Background:
Men may also experience bone loss due to declining testosterone levels with aging which might be associated with osteoblastic activity. The objective of the study was to find out the association of osteoporosis with testosterone levels amongst young males.
Methods:
Participants (1000) were enrolled, age +45 years, from free orthopedics camps in different towns of Karachi after an informed consent. Bonemineral density was assessed by heel scan device. Blood samples were taken to assess Testosterone through Elisa. Information on demographics, general and medical history was obtained by an interviewer-administered questionnaire. This cross-sectional study was conducted from February 2014 to April 2015. The study protocol was duly approved by Ziauddin University Ethics Review Committee.Data was analyzed using SPSS version 20. P value less than 0.05 was taken as significant.
Results:
A total of 987 subjects were finalized. Testosterone levels were low in 359(36.4%) subjects and normal in 628(63.6%). 113 had T-score ≥-2.5 on Single x-ray absorptiometry (SXA), and were considered to be osteoporotic according to WHO criteria and rest 874 were taken as controls. Out of 113 subjects, 82(72.6%) had low,whereas,31(27.4%) had normal levels of testosterone. Odds ratio for osteoporosis verses testosterone deficiency came out to be 6.65 (2.70-21.63), p-value was 0.0001 (win pepi version 11.39).When education was seen with the frequency of osteoporosis it was observed that the prevalence was seen higher in those who had attained matriculation or intermediate/ graduation (p-value 0.01).
Conclusion:
Osteoporosis was found associated with testosterone deficiency with an odds ratio of 6.65 (2.70-21.63) and P- value of 0.0001 (win pepi version 11.39).
Syed Sohail Abbas, Saeeda Baig, Sohail Rafi, Wasfa Farooq, Asma Niyaz, Syeda Abia Amber. (2018) Osteoporosis and its Association with Testosterone Levels in Males in Pakistan Population, The Pakistan Journal of Medicine and Dentistry, Volume-7, Issue-4.
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