Abstract
Background:
A number of demographic and clinical variables have an effect on NT-proBNP, which has been used as a serological marker for evaluating cardiovascular disease. This study was done to evaluate the effect of these confounding variables on NT-proBNP.
Methods:
A cross-sectional study was performed on 50 Coronary artery bypass grafting (CABG) patients. Data of demographic and clinical variables was obtained from the patients. Samples of serum and pericardial fluid were collected and NT-proBNP levels were assessed in all the samples by an electrochemiluminescence immunoassay. Transformation of NT-proBNP values into log was done. The effect of all the variables on pericardial fluid and serum levels of log NT-proBNP was statistically calculated.
Results:
In this study NT-proBNP was found to be increased significantly with age (p-value of 0.01 and 0.02). Males constituted 86 % of our sample and NT-proBNP was insignificantly higher in men than women (p =0.227 and 0.245). There was also no significant difference between the mean NT-proBNP levels in hypertensives and diabetics.
Conclusion:
Age is the confounding variable which has significant effect on NT-proBNP concentrations while other demographic and clinical variables did not show a significant effect. Therefore, a minute adjustment should be made for the independent effects of age.
Sofia Amjad, Sobia Hassan, Amna Faruqi . (2017) Effect Of Demographic And Clinical Variables On Nt-Probnp, The Pakistan Journal of Medicine and Dentistry, Volume-6, Issue-4.
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