Abstract
Background:
Oral cancer is regarded as the sixth most common malignant tumor and is one of the leading cause of death. Lymph node metastasis is a major factor for the prognosis of oral squamous cell carcinoma (OSCC). The objective of study was to compare the lymph node metastases with different histopathological parameters to identify high risk patients with the need for extensive treatment plans.
Methods:
140 histologically proven OSCC patients visiting Ziauddin College of Dentistry were included in this study. The clinico-pathological parameters were compared by using Chi-square, Kruskal-Willis and Mann-Whitney.
Results:
There were 90 male and 50 female patients with 29.8% in 49-58 years age group. Buccal mucosa was the most common site of tumor. The predominant morphology of OSCC was moderately differentiated OSCC with stage IV disease. Lymph node metastasis was present in 48.6% of patients. Perineural invasion (22.9%), lymphovascular invasion (8.6%) and distant metastasis (11.1%) were also recorded. The mean tumor size was 3.45mm ± 1.95mm and mean tumor thickness was 1.8 ± 1.6mm.
Conclusion:
A significant association between grade, stage, tumor size, tumor thickness and distant metastasis with lymph node involvement was found. However further studies with larger sample size are required to validate these results.
Sana Mirza, Naila Irum Hadi, Saima Akram, Noor-ul-Wahab, Zohaib Akram. (2016) Histopathological Predictors Of Nodal Metastases In Oral Squamous Cell Carcinoma, The Pakistan Journal of Medicine and Dentistry, Volume-5, Issue-3.
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