Abstract
Chronic myelogenous leukemia (CML) results from neoplastic transformation of a hematopoietic stem cell. It is cytogenetically characterized by the presence of Philadelphia chromosome which results from reciprocal translocation t(9;22) that juxtaposes the ABL gene on chromosome 9 with breakpoint cluster region (BCR) on chromosome 22 generating BCR-ABL oncogene. All BCR-ABL fusion proteins display activated tyrosine kinase activity. Their different types are associated with different clinical course and prognosis. We report a rare case of e1a3 BCR-ABL transcript. So far only 4 cases in patients with CML have been reported.
Najia Tabassum, Rubina Ghani, Mohammad Saboor, Moinuddin Moinuddin. (2015) Chronic Myeloid Leukemia with Rare e1a3 BCR-ABL Transcript, The Pakistan Journal of Medicine and Dentistry, Volume-4, Issue-1.
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