Abstract
Background:
Levofloxacin is a broad spectrum quinolone, widely used to treat infections caused by gram negative and gram positive bacteria. Development of resistance by pathogens against different broadspectrum antibiotics is increasing and now becoming a global issue.
Objectives:
The aim of the study is to evaluate the current sensitivity pattern of levofloxacin against various common clinical isolates like Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa,and Klebsiellapneumoniae.
Methods:
A total of one hundred and ten samples were collected from different pathological laboratories of Karachi, Pakistan. The above mentioned pathogens were isolated from blood, stool/urine, sputum, skin samples.
Results:
Results show least resistance of levofloxacin against E.coli (27.5%), and P.aeruginosa (27%), while S.aureus possessed highest resistance (45%).
Conclusion:
Study concluded levofloxacin still possesses excellent anti-microbial activity against common pathogens. Routine monitoring and surveillance is further required to ensure effective treatment regimens to community.
Rabia Bushra, Mehwish Rizvi, Maqsood Ahmed, Shazia Alam, Nusrat Bano. (2013) In-vitro Susceptibility of Levofloxacin against Different Clinical Isolates, The Pakistan Journal of Medicine and Dentistry, Volume-2, Issue-3.
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