Abstract
Background: Thyroid hormones have a vital role in metabolism of lipids, cholesterol etc. They also have an
important role in phosphorous and calcium homeostasis by their direct effect on bone turnover. The
objective of present study was to find the significant differences of T3, T4, TSH, lipid profile (HDL, LDL,
vLDL, TG, Cholesterol), electrolytes and minerals (sodium, potassium, chloride, phosphorus, calcium) between
control group and hypothyroidism patients.
Methods: Blood samples were collected from 72 patients and 12 control after their consent. Serum was used to
determine biochemical parameters using standard protocol. Data obtained were statistically analyzed using “t”
student test.
Results: The level of TSH was significantly higher in female and male hypothyroidism patients (p < 0.01) as
compared to control and it was inversely related to the level of T3 and T4. Patients with hypothyroidism have
increased level of LFTs profile especially cholesterol and Triglycerides levels both in males and females. In
hypothyroidism, the level of glomerulus filtrate rate decrease especially sodium level but thyroid hormonal
disturbance does not affect serum electrolyte level. The serum phosphorus and calcium levels change
significantly in thyroid disorder.
Conclusion: Hypothyroidism is associated with increased TSH level and decreased T3 and T4 levels but does
not appear to be associated with abnormalities in lipid profile. The serum phosphorus and calcium levels change
significantly in thyroid disorder, Treatments of its primary causes should be given and if it is possible minerals
can be added to avoid further bone complications.
Nida Zahra, Ahmad Ali, Saima Kousar, Arif Malik, Ahmad Zaheer, Imran Riaz Malik. (2020-2021) Study on significant changes in calcium, phosphorus and thyroid hormones level in hypothyroidism patients, Advancements in Life Sciences, Volume-8, Issue-1.
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