Abstract
The current work was aimed to find the effect of Bisphenol A (BPA) which is widely used in the manufacturing of epoxy resins and variety of plastics to which humans are exposed routinely. BPA (12.5%) was injected in mice for consecutive 15 days while control animals were not exposed to any treatment (n=3). Serum samples were processed
for the estimation of total protein and albumin and aminotransaminases activity. The sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) was also run to analyze protein bands. Statistically significant increase in total protein contents, albumin and aminotransaminases were noted in sample in comparison with control.
Comparative analysis between experimental and control samples revealed protein fractions (KDa) of 149, 132, 101, 72, 75 and (163, 114, 91, 75, 72, respectively. Conclusively, it can be stated that extensive use of BPA in various application cause serious health hazards, as noted by changes in serum proteins and transaminases. Therefore,
further investigation of its toxicity is necessary in order to consider it safe.
Muddasir Hassan Abbas, Noor Fatima, Syed Shahid Imran Bukhari, Asma Rashid khan, Nadeem Sheikh. (2016) Variations in proteins and transaminases following experimental induction of Bisphenol A in mice, Punjab University Journal of Zoology, Volume 31, Issue 2.
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