Abstract
Numerous effects on metabolism of Lipids, its absorption, amalgamation, and control is under the influence of Thyroid Hormone. The scientists at international are exploring the possibility of establishing a link between subclinical hypothyroidism and lipids. We conducted this research to test the hypothesis that TSH, and levels of LDL-C and HDL-C are significantly associated in subjects with SCH.
Methods: This cross sectional study was conducted at Physiology Department, KEMU in collaboration with Centre for Nuclear Medicine (CENUM), Mayo Hospital & KEMU, Lahore. Simple Random sampling technique was employed to collect the sample. A total of 100 cases were selected (50 with SCH and 50 with Thyroid Profile within normal range as control) Levels of TSH, LDL-C and HDL-C were measured in fasting serum samples.
Results: TSH levels in subclinical hypothyroidism SCH were 8.69 mlU/L and Euthyroid showed to be
1.39 mlU/L. Mean HDL levels were 39.74 mg/dL in Subclinical Hypothyroidism subjects and 43.48mg/dL in euthyroid. The LDL-C pattern was in SCH 182.82 mg/dL and Euthyroids 161.24 mg/dL.
Conclusion: The Subclinical hypothyroidism has statistically significant effect in lowering HDL-C and increasing LDL-C level.
Abstract
Numerous effects on metabolism of Lipids, its absorption, amalgamation, and control is under the influence of Thyroid Hormone. The scientists at international are exploring the possibility of establishing a link between subclinical hypothyroidism and lipids. We conducted this research to test the hypothesis that TSH, and levels of LDL-C and HDL-C are significantly associated in subjects with SCH.
Methods: This cross sectional study was conducted at Physiology Department, KEMU in collaboration with Centre for Nuclear Medicine (CENUM), Mayo Hospital & KEMU, Lahore. Simple Random sampling technique was employed to collect the sample. A total of 100 cases were selected (50 with SCH and 50 with Thyroid Profile within normal range as control) Levels of TSH, LDL-C and HDL-C were measured in fasting serum samples.
Results: TSH levels in subclinical hypothyroidism SCH were 8.69 mlU/L and Euthyroid showed to be
1.39 mlU/L. Mean HDL levels were 39.74 mg/dL in Subclinical Hypothyroidism subjects and 43.48mg/dL in euthyroid. The LDL-C pattern was in SCH 182.82 mg/dL and Euthyroids 161.24 mg/dL.
Conclusion: The Subclinical hypothyroidism has statistically significant effect in lowering HDL-C and increasing LDL-C levels.
Key words: Subclinical hypothyroidism, TSH, HDL-C, LDL-C
